DAMP

The role of pre-pregnancy and pre-natal danger associated molecular patterns in pregnancy complications (DAMP) - LIFE Study Samples

15–20%

Pregnancy Loss Rate

~80%

First Trimester Cases

10+ Markers

Biomarkers Studied

Overview

Early pregnancy loss is non-induced embryonic or fatal death or passage of products of conception before 20 weeks’ gestation. Early pregnancy loss is also termed as spontaneous abortion or miscarriage. The World Health Organization (WHO) defines it as expulsion or extraction of an embryo or fetus weighing 500gm or less. National Health Portal of India, states, spontaneous abortion in the first trimester is common, affecting at least 15–20% of the clinically recognized pregnancies. Approximately 80% of all cases of pregnancy loss occur within the first three months of pregnancy (first trimester). This study is taken with the cohort of pregnant women of LIFE study to understand the factors associated with early pregnancy serum markers of cellular damage, innate immune signaling, angiogenesis and preeclampsia subtypes to promote maternal health.

Aim

Determine if circulating pre-pregnancy and first trimester biomarkers of placental dysfunction (EGFL7, PIGF, sFLT-1, PP-13) are associated with SAB
Determine if circulating pre-pregnancy and early pregnancy DAMPS (HG BM-1,HSP70) and innate immune signaling biomarkers (pentraxin-3) are associated with SAB
Determine if pre-pregnancy and early pregnancy circulating markers of oxidative stress (MDA, GDH) are associated with SAB.

Objectives

Examine the relationship between early pregnancy serum markers of cellular damage, innate immune signaling, angiogenesis and preeclampsia subtypes.

Status of the project

Project completed.