Computational model can help society translate observations into an anticipation of future events, act as a test bed for ideas, extract value from data and ask questions about behaviors. A key feature of today’s computational models in health is that they are able to study a biological system at multiple levels, including molecular processes, cell to cell interactions, and how those interactions result in changes at the tissue and organ level. This enables safe and effective new therapeutics to advance more efficiently through the different stages of clinical trials. Simulation software is now starting to be used to develop highly accurate personalized human organs, medical devices and biologics. Today, simulation technologies can detect how these models will respond under stress or in any lifelike situation. When finally brought to market, the device will result in the highest levels of quality and safety for both patients and providers.